کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116684 | 1216371 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A prospective study evaluating the role of donor-specific anti-endothelial crossmatch (XM-ONE assay) in predicting living donor kidney transplant outcome
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کلمات کلیدی
SABEPCsFSGSUrinalysis - آزمایش ادرارHuman leukocyte antigen - آنتی ژن لوسکسی انسانAnti-endothelial cell antibodies - آنتیبادی های ضد اندوتلیالSingle Antigen Bead - آنتیژن تک مهره ایHLA - آنتیژن گلبول سفید انسانیstandard of care - استاندارد مراقبتESRD یا end stage renal disease - بیماری کلیوی در مرحله نهایی endothelial precursor cells - سلول های پیش سلول اندوتلیالSOC - سیستم روی یک تراشهend stage renal disease - مرحله نهایی بیماری کلیویFocal segmental glomerulosclerosis - گلومرول اسکلروز بخش مرکزی فوکوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Anti-endothelial cell antibodies (AECAs) may play a role in allograft rejection. We prospectively tested 150 consecutive living donor kidney transplant recipients, with transplants performed at Northwestern Memorial Hospital between January and December 2010, using the donor-specific endothelial (XM-ONE) crossmatch. 88/150 Patients received standard of care (SOC) immunosuppression and analyzed separately, in addition to the complete study cohort. Patients were followed for one year and XM-ONE results were analyzed in relation to occurrence of acute rejection, proteinuria, serum creatinine levels, and biopsy proven fibrosis. No correlation was found between XM-ONE results and protocol or “for-cause” biopsy proven acute rejection or vasculopathy at 12 months. When IgG+ and IgM+ results of the XM-ONE assay were combined, a correlation with proteinuria at 12 months was observed (p = 0.047). Although IgG + XM-ONE results were associated with significantly higher creatinine at 6 months (p = 0.018), significance was lost at 12 months. Conversely, patients with an IgM + XM-ONE crossmatch had significantly lower creatinine at 1 month (p = 0.019), 3 months (p = 0.0045), and 6 months (p = 0.038) post-transplant, but lost statistical significance at 12 months (p = 0.67) post-transplant. In summary, the presence of AECAs as determined by a positive XM-ONE result was not predictive of overall poorer graft outcome after one year in our center.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 74, Issue 11, November 2013, Pages 1431-1436
Journal: Human Immunology - Volume 74, Issue 11, November 2013, Pages 1431-1436
نویسندگان
Jennifer R. Zitzner, Shivani Shah, Chunfa Jie, Wendy Wegner, Anat R. Tambur, John J. Friedewald,