کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116844 | 1216395 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High-resolution HLA haplotype frequencies of stem cell donors in Germany with foreign parentage: How can they be used to improve unrelated donor searches?
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کلمات کلیدی
CPUHSCTSBTHWEGermany - آلمانHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیAustria - اتریشSpain - اسپانیاExpectation-Maximization - انتظار-حداکثر سازیUnited States of America - ایالات متحده آمریکاItaly - ایتالیاBosnia and Herzegovina - بوسنی و هرزگوینsequencing-based typing - تایپ کردن مبتنی بر توالیTurkey - ترکیهHardy–Weinberg equilibrium - تعادل هاردی-وینبرگRam - رمRomania - رومانیLinkage disequilibrium - عدم تعادل پیوستگیGenetic distance - فاصله ژنتیکیRussian Federation - فدراسیون روسیهFrance - فرانسهKazakhstan - قزاقستانPoland - لهستانThe Netherlands - هلند، کشور هلندcentral processing unit - واحد پردازش مرکزیUnited Kingdom - پادشاهی متحده بریتانیاPortugal - پرتغالHematopoietic stem cell transplantation - پیوند مغز استخوانCroatia - کرواسیGreece - یونان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High-resolution HLA haplotype frequencies of stem cell donors in Germany with foreign parentage: How can they be used to improve unrelated donor searches? High-resolution HLA haplotype frequencies of stem cell donors in Germany with foreign parentage: How can they be used to improve unrelated donor searches?](/preview/png/6116844.png)
چکیده انگلیسی
In hematopoietic stem cell transplantation, human leukocyte antigens (HLA), usually HLA loci A, B, C, DRB1 and DQB1, are required to check histocompatibility between a potential donor and the recipient suffering from a malignant or non-malignant blood disease. As databases of potential unrelated donors are very heterogeneous with respect to typing resolution and number of typed loci, donor registries make use of haplotype frequency-based algorithms to provide matching probabilities for each potentially matching recipient/donor pair. However, it is well known that HLA allele and haplotype frequencies differ significantly between populations. We estimated high-resolution HLA-A, -B, -C, -DRB1 haplotype and allele frequencies of donors within DKMS German Bone Marrow Donor Center with parentage from 17 different countries: Turkey, Poland, Italy, Russian Federation, Croatia, Greece, Austria, Kazakhstan, France, The Netherlands, Republic of China, Romania, Portugal, USA, Spain, United Kingdom and Bosnia and Herzegovina. 5-locus haplotypes including HLA-DQB1 are presented for Turkey, Poland, Italy and Russian Federation. We calculated linkage disequilibria for each sample. Genetic distances between included countries could be shown to reflect geography. We further demonstrate how genetic differences between populations are reflected in matching probabilities of recipient/donor pairs and how they influence the search for unrelated donors as well as strategic donor center typings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 74, Issue 3, March 2013, Pages 330-340
Journal: Human Immunology - Volume 74, Issue 3, March 2013, Pages 330-340
نویسندگان
Julia Pingel, Ute V. Solloch, Jan A. Hofmann, Vinzenz Lange, Gerhard Ehninger, Alexander H. Schmidt,