Dynamics of HCV genotype 4 resistance-associated variants during virologic escape with pIFN/RBVÂ +Â daclatasvir: A case study using ultra deep pyrosequencing

This is the first report to describe DCV-resistance in patients infected with GT4d, supporting a possible role for a recently described RAV (L28S), and presenting the dynamics of HCV quasispecies during therapy failure, with indications of changes of diversity and association of mutations.