کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6120183 1592357 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay
چکیده انگلیسی
New mutations in the UL97- and UL54-gene of HCMV are still detected continuously. Furthermore, several mutations occurring in the same codon often show divergent phenotypes and the accumulation of multiple mutations in one virus strain may lead to increased or decreased drug-resistance. Therefore, characterization of newly detected mutations by marker transfer analysis is essential to confirm that genotypically detected mutations can produce phenotypic resistance. These results allow reliable interpretation of fast genotypic methods generally used in diagnostics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 69, August 2015, Pages 150-155
نویسندگان
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