کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6120623 | 1218988 | 2014 | 9 صفحه PDF | دانلود رایگان |
- VZV viremia occurs â5 to +4 days of varicella; VZV DNAemia occurs at â8/â10 to +7 days.
- VZV DNA in blood/saliva is useful for diagnosis and prognosis of atypical varicella.
- VZV DNAemia is present at the onset of herpes zoster and for many weeks thereafter.
- VZV DNA in blood/saliva facilitates the diagnosis of atypical cases of herpes zoster.
Varicella-zoster virus (VZV) can be detected in the blood from approximately 5 days before to 4 days after varicella. VZV DNA, primarily in T-lymphocytes, is detected as early as 8-10 days prior to rash and can persist for a week. The duration and magnitude of VZV DNAemia correlates with immune status and the efficacy of antiviral therapy. VZV DNA is also readily detected in the oropharynx just prior to rash and for 1-2 weeks thereafter. Detection of VZV DNA in blood and saliva has been useful for diagnosis and prognosis in atypical cases of varicella. Herpes zoster (HZ) is also characterized by VZV DNAemia at onset and for many weeks thereafter, and VZV DNA is present in the oropharynx shortly after HZ onset. Detection of VZV DNA in blood and saliva facilitates the diagnosis of zoster sine herpete and other atypical manifestations of VZV reactivation, such as neurologic syndromes when cerebrospinal fluid is not available, Bell's palsy, and atypical pain syndromes. VZV DNA is sometimes present in the blood and saliva of asymptomatic individuals. In total these observations extend understanding of the pathophysiology and epidemiology of VZV, and increasingly contribute to the clinical management of VZV infections.
Journal: Journal of Clinical Virology - Volume 61, Issue 4, December 2014, Pages 487-495