Viral load in patients infected with dengue is modulated by the presence of anti-dengue IgM antibodies

Comparison of viremia levels in sera from patients positive or negative for dengue IgM antibodies showed that viral load was significantly higher (p ≤ 0.0001) in patients negative for IgM antibodies. In contrast, levels of circulating NS1 were found unaffected by the presence of IgM (p = 0.0038). Thus, dengue virus specific IgM antibodies in sera seem to be a strong negative modulator of viremia levels in patient's sera.