کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6122928 | 1219612 | 2015 | 9 صفحه PDF | دانلود رایگان |
- This study includes the largest cohort in genetic association studies of SARS.
- The GG genotype at CCL2 G-2518A was associated with an increased risk of SARS-CoV infection.
- The MBL B allele was associated with an increased risk of SARS-CoV infection.
- SNPs of CCL2 and MBL cumulatively increase susceptibility to SARS-CoV infection.
- The joint population attributable fraction (PAF) for these two SNPs is 28.5%.
SummaryObjectivesTo assess associations between the functional polymorphisms G-2518A at the chemokine (C-C motif) ligand 2 gene (CCL2) and mannose binding lectin (MBL) codon 54 variant (A/B) and susceptibility to SARS.MethodsWe genotyped the CCL2 G-2518A and MBL codon 54 variant (A/B) in 4 case-control populations of Chinese descent, totally consisting of 932 patients with SARS and 982 control subjects.ResultsBoth the high-CCL2-producing GG genotype and the low-MBL-producing B allele were consistently associated with increased risks of SARS-CoV infection in all 4 case-control populations (joint PÂ =Â 1.6Â ÃÂ 10â4 and 4.9Â ÃÂ 10â8, for CCL2 and MBL respectively), with no interaction between polymorphisms could be detected. Furthermore, all the 4 case-control studies demonstrated a cumulative effect on risk of SARS-CoV infection for the combination of polymorphisms (joint PÂ =Â 1.3Â ÃÂ 10â10). However, tests using the area under the curve (AUC) indicated that at this stage, the polymorphisms were unlikely to be appropriate for risk prediction testing because of low AUC values (all <66%). Additionally, no association was observed between the polymorphisms and severity of SARS.ConclusionsThe CCL2 G-2518A and MBL codon 54 variant have a significantly cumulative effect on increased risk of SARS-CoV infection.
Journal: Journal of Infection - Volume 71, Issue 1, July 2015, Pages 101-109