کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6123151 1219621 2015 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation
چکیده انگلیسی


- We studied false-positive Aspergillus galactomannan in allogeneic HSCT recipients.
- We focused on galactomannan index value and its kinetics.
- A false-positive galactomannan test was frequently seen after allogeneic HSCT.
- Increase in galactomannan was associated with reduced false-positive results.

SummaryObjectivesWe evaluated the incidence of and risk factors for false-positive Aspergillus galactomannan (GM) antigenemia in allogeneic hematopoietic stem cell transplantation (HSCT). We also focused on the GM index value and its kinetics.MethodsPatients who underwent their first allogeneic HSCT at our center between June 2007 and December 2012 were included (n = 172). Episodes of positive GM tests were classified as either “true-positive”, which fulfilled the EORTC criteria for proven or probable invasive aspergillosis (IA), or “false-positive”, which was not accompanied by clinical findings. The remaining cases were regarded as “inconclusive”.ResultsThe one-year cumulative incidences of IA and positive GM tests were 10.1% and 48.1%, respectively. Among 148 episodes of positive GM tests, 97(65.5%), 23(15.5%), and 28(19.0%) were classified as false-positive, true-positive and inconclusive, respectively. In the first episodes of positive GM tests in each patient (false-positive = 67, others = 30), an increase in the GM value in the first two measurements, neutropenia, and use of anti-mold agents at positive GM episode were associated with a significantly lower possibility of false-positive results according to a multivariate analysis.ConclusionsA false-positive GM test was frequently seen after allogeneic HSCT. An increase in the GM value may increase its positive predictive value.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 70, Issue 5, May 2015, Pages 520-540
نویسندگان
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