In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis

The current MMP-13 activity probe is suitable for the discrimination between DMM and sham or contralateral knees 8 weeks after surgery, when cartilage loss is typified by the appearance of small fissures up to the tidemark, but not earlier. This activity correlates with the histological damage observed.