کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6124938 | 1220154 | 2014 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies
ترجمه فارسی عنوان
تداخل رابط گرافیکی استخوان و غضروف در استئوآرتریت: مسیرهای بالقوه و راهبردهای درمانی آینده
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کلمات کلیدی
آرتروز، رابط بین غضروف بون؟ استخوان زیرچندال، تداخل، تعامل مولکولی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
چکیده انگلیسی
Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a process of wear and tear but rather abnormal remodelling and joint failure of an organ. The bone-cartilage interface is therefore a functioning synergistic unit, with a close physical association between subchondral bone and cartilage suggesting the existence of biochemical and molecular crosstalk across the OA interface. The crosstalk at the bone-cartilage interface may be elevated in OA in vivo and in vitro. Increased vascularisation and formation of microcracks associated with abnormal bone remodelling in joints during OA facilitate molecular transport from cartilage to bone and vice versa. Recent reports suggest that several critical signalling pathways and biological factors are key regulators and activate cellular and molecular processes in crosstalk among joint compartments. Therapeutic interventions including angiogenesis inhibitors, agonists/antagonists of molecules and drugs targeting bone remodelling are potential candidates for this interaction. This review summarised the premise for the presence of crosstalk in bone-cartilage interface as well as the current knowledge of the major signalling pathways and molecular interactions that regulate OA progression. A better understanding of crosstalk in bone-cartilage interface may lead to development of more effective strategies for treating OA patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Osteoarthritis and Cartilage - Volume 22, Issue 8, August 2014, Pages 1077-1089
Journal: Osteoarthritis and Cartilage - Volume 22, Issue 8, August 2014, Pages 1077-1089
نویسندگان
X.L. Yuan, H.Y. Meng, Y.C. Wang, J. Peng, Q.Y. Guo, A.Y. Wang, S.B. Lu,