کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6155868 | 1247880 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats
ترجمه فارسی عنوان
متفورمین باعث کاهش دی متیل آرژینین نامتقارن و جلوگیری از فشار خون بالا در موش های خودبهخود فشار خون می شود
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کلمات کلیدی
ASRPRMTDDAHsDMAWKYNOSAARCATADMAcationic amino acid transporter - حمل و نقل اسید آمینه اسید کاتیونیSpontaneously Hypertensive Rat - خودآزمایی موش بالینیDimethylarginine dimethylaminohydrolase - دی متیل آرژینین دی متیل آمینویدرولازsymmetric dimethylarginine - دی متیل آرژینین متقارنasymmetric dimethylarginine - دی متیل آرژینین نامتقارنShr - شریnitric oxide synthase - نیتریک اکسید سنتازWistar Kyoto - ویستار کیوتوprotein arginine methyltransferase - پروتئین آرژینین متیل ترانسفراز
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Elevated asymmetric dimethylarginine (ADMA) levels and nitric oxide (NO) deficiency are associated with the development of hypertension. Metformin, an antidiabetic agent, is a structural analog of ADMA. We examined whether metformin can prevent the development of hypertension in spontaneously hypertensive rats (SHRs) by restoration of ADMA-NO balance. SHRs and control normotensive Wistar-Kyoto (WKY) rats were assigned to 4 groups (N = 8 for each group): untreated SHRs and WKY rats, metformin-treated SHRs and WKY rats. Metformin-treated rats received metformin 500 mg/kg per day via oral gavage for 8 weeks. All rats were sacrificed at the age of 12 weeks. We found an increase in the blood pressure of SHRs was prevented by metformin. ADMA levels in the plasma and lung were elevated in SHRs, which metformin prevented. Lung dimethylarginine dimethylaminohydrolase (DDAH, ADMA-metabolizing enzyme) activity was lower in SHRs than WKY rats. Next, metformin had no effect on protein arginine methyltransferase 1 (ADMA-synthesizing enzyme), DDAH-1, DDAH-2, NO synthase enzymes, and DDAH activity in the kidney. Moreover, metformin increased the levels of NO in kidney. Conclusively, the observed antihypertensive effect of metformin in SHRs is because of the restoration of the ADMA-NO pathway. Our findings support the consideration of metformin as an antihypertensive agent for diabetic patients with prehypertension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 164, Issue 6, December 2014, Pages 452-459
Journal: Translational Research - Volume 164, Issue 6, December 2014, Pages 452-459
نویسندگان
Chih-Min Tsai, Hsuan-Chang Kuo, Chien-Ning Hsu, Li-Tung Huang, You-Lin Tain,