کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6156118 1247908 2015 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmentally induced epigenetic transgenerational inheritance of disease susceptibility
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Environmentally induced epigenetic transgenerational inheritance of disease susceptibility
چکیده انگلیسی
Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to epigenetic changes that are in turn related to increased susceptibility to disease. The focus of this review is on the transgenerational inheritance of such epigenetic abnormalities (epimutations), and how it is that these inherited epigenetic abnormalities can lead to increased disease susceptibility, even in the absence of continued environmental insult. Observations of environmental toxicant specificity and exposure-specific disease susceptibility are discussed. How epimutations are transmitted across generations and how epigenetic changes in the germline are translated into an increased disease susceptibility in the adult is reviewed with regard to disease etiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 165, Issue 1, January 2015, Pages 12-17
نویسندگان
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