کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6156484 1598249 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy
چکیده انگلیسی
Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process, is an important mechanism for cellular homeostasis and survival during pathologic stress conditions in the kidney, such as ischemia-reperfusion injury (IRI). However, stimulation of autophagy has been described to both improve and exacerbate IRI in the kidney. We summarize the current understanding of autophagy in renal IRI and discuss possible reasons for these contradictory findings. Furthermore, we hypothesize that autophagy plays a dual role in renal IRI, having both protective and detrimental properties, depending on the duration of the ischemic period and the phase of the IRI process. Finally, we discuss the influence of currently used diuretics and immunosuppressive drugs on autophagy, underscoring the need to clarify the puzzling role of autophagy in renal IRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 66, Issue 4, October 2015, Pages 699-709
نویسندگان
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