Keywords: SCA21; spinocerebellar ataxia type 21; TMEM240; transmembrane protein 240; LAMP2A; lysosome-associated membrane protein 2a; TSG101; tumor susceptibility gene 101; Iba1; ionized calcium-binding adapter molecule 1; GFAP; glial fibrillary acidic protein; LC3
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Keywords: Parkinson's disease; Actinobacteria; Actinomyces; Fungi; Ray fungus; Alpha-synuclein; Hyphae; Spores; Macroautophagy; Mold; Gut microbiota; Olfactory;
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: Atg; autophagy-related gene; Baf A1; bafilomycin A1; BHMT; betaine homocysteine methyltransferase; 14C; radiocarbon; Con A; concanamycin A; F; farad; GFP; green fluorescent protein; GST; gluthathione S-transferase; 3H; tritium; KO; knockout; LDH; lactate
Keywords: Parkinson's disease; Autophagy; Macroautophagy; CMA; α-synuclein; LRRK2; VPS35; PINK1; Parkin; GBA; ATG13A2
Connecting chaperone-mediated autophagy dysfunction to cellular senescence
Keywords: Aging; Cellular senescence; Chaperone-mediated autophagy; Macroautophagy; Proteostasis;
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology
Keywords: ACSF; artificial cerebral spinal fluid; APP; amyloid precursor protein; BBB; blood-brain-barrier; BCECs; brain capillary endothelial cells; C57Bl6/J; strain of mice for MOG-induce EAE and cuprizone studies; CNS; central nervous system; DKO; Gas6â/âAxl
Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy
Keywords: Urate; Macroautophagy; mTOR; SNCA/α-synuclein; Parkinson's disease;
Autophagy: An overview and its roles in cancer and obesity
Keywords: Macroautophagy; Microautophagy; CMA; Cell survival; Cell killing;
A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy
Keywords: BAG3; Hsp70; Macroautophagy; SNCA; SQSTM1;
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Keywords: AMPK; AMP-activated protein kinase; AO; acridine orange; AVOs; acidic vesicular organelles; FGF-2; fibroblast growth factor 2; Grb2; growth factor receptor binding protein 2; Rab13; Ras-related protein in brain 13; HA; hemagglutinin; HRP; Horseradish pero
Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells
Keywords: Neuroblastoma; Oxyresveratrol; Macroautophagy; Caspase-independent; mTOR signaling; p38 MAPK;
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
Research reportβ-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression
Keywords: Myocyte enhancer factor 2D; β-Asarone; Chaperone-mediated autophagy; Macroautophagy; α-Synuclein; HSP70/MAPK/MEF2D/Beclin-1 pathway;
Breaking BAG: The Co-Chaperone BAG3 in Health and Disease
Keywords: Bcl-2; Hsc/Hsp70; protein quality control; BAG1–BAG3 switch; proteasome; macroautophagy
In vivo and in vitro studies of the role of lyophilised blond Lager beer and some bioactive components in the modulation of degenerative processes
Keywords: Beer; Antigenotoxicity; Drosophila melanogaster; Tumour cells; Cytotoxicity; Macroautophagy; Agarose (PubChem CID: 11966311); Etanol (PubChem CID: 702); Ethidum bromide (PubChem CID: 14710); Folic acid (PubChem CID: 6037); Hydrogen peroxide (H2O2) (PubChe
Autophagy transduces physical constraints into biological responses
Keywords: Macroautophagy; Shear stress; Compression; Stretching; Autophagy-related;
Using enhanced-mitophagy to measure autophagic flux
Keywords: Macroautophagy; Autophagic flux; Mitophagy; Parkin;
Macroautophagy and microautophagy in relation to vacuole formation in mesophyll cells of Dendrobium tepals
Keywords: Mesophyll; Macroautophagy; Microautophagy; Tepal; Vacuole
Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy
Keywords: Autophagy; macroautophagy; cell death; ischemia-reperfusion injury (IRI); renal IRI; acute kidney injury (AKI); stress response; animal model; kidney transplantation; delayed graft function; immunosuppression; review;
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy
Keywords: Actb; β-actin; AMPK; adenosine monophosphate protein kinase; Bgn; biglycan; CDK; cyclin-dependent kinase; Dcn; decorin; EGFR; epidermal growth factor receptor; GFP; green fluorescent protein; IGF-IR; insulin-like growth factor receptor I; LC3; microtubul
Contribution of autophagy to antiviral immunity
Keywords: Autophagy; Macroautophagy; Virus; Innate immunity; Adaptive immunity;
Roles of bovine viral diarrhea virus envelope glycoproteins in inducing autophagy in MDBK cells
Keywords: Bovine viral diarrhea virus; Autophagy; Viral envelope glycoproteins Erns, E1 and E2; Autophagy; macroautophagy; TCID50; 50% tissue culture infective dose; GFP-LC3; green fluorescent-microtubule-associated protein light chain 3 fusion protein; MOI; multip
Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes
Keywords: Palmitate; Docosahexaenoic acid; Muscle atrophy; Proteolysis; Macroautophagy; FoxO3
Degradation of AF1Q by chaperone-mediated autophagy
Keywords: 3-MA; 3-methyladenine; 6-AN; 6-aminonicotinamide; AML; acute myeloid leukemia; CMA; chaperone-mediated autophagy; CQ; chloroquine; HBSS; Hanks balanced salt solution; HSPA8; heat shock 70 kDa protein 8; LAMP-2 A; lysosome-associated membrane protein 2A; A
TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line
Keywords: sIBM; sporadic inclusion body myositis; APP; amyloid precursor protein; 3MA; 3-methyladenine; CQ; chloroquine; FKBP12; FK-binding protein 12; mTORC1; mammalian target of rapamycin complex1; BACE1; β-site APP-cleaving enzyme 1; AD; Alzheimer's dementia; M
Inhibition of LRRK2 kinase activity stimulates macroautophagy
Keywords: LRRK2; Leucine Rich Repeat Kinase 2; mTOR; Mammalian target of rapamycin; ROC; Ras of Complex Proteins; COR; C-terminal of ROC domain; SDS; Sodium dodecyl sulphate; EDTA; Ethylene di-ammonium tetra acetic acid; DPBS; Dulbecco's phosphate buffered saline;
Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells
Keywords: CaMKKβ; Macroautophagy; mTOR; Pterostilbene; Vascular endothelial cell
High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: Comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs
Keywords: Quinacrine; Polymorphonuclear leukocytes; Lymphocytes; Ion trapping; Vacuolar ATPase; Macroautophagy;
Autophagy regulation and its role in cancer
Keywords: Macroautophagy; Tumorigenesis; Signaling pathways; Tumor suppression; Oncogenes
Dynamics of macroautophagy: Modeling and oscillatory behavior
Keywords: Modeling; Numerical simulation; Macroautophagy; Oscillation; Autophagosome; Autolysosome; Protein and organelle; ATP; Amino acid;
Mitochondrial Ca2+ signals in autophagy
Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts
Keywords: ATG/Atg; autophagy-related gene; ATP6V0A1; encoding gene of isoform a1 of vacuolar H+-ATase V0 domain; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; LAMP1; lysosomal-associated membrane protein 1; LC3; microtubule-associated-protein-light-chain
Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival
Keywords: Chaperone-mediated autophagy; Macroautophagy; Hypoxia; LAMP-2A; Brain ischemia;
ReviewMitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging
Keywords: Autophagy; Macroautophagy; Mitophagy; Lysosome; Parkin; PINK1; Parkinson's disease; Alzheimer's disease; Huntington's disease; Mitochondrial dynamics; Fission; Fusion; Aging;
Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: Implication of a free radical hypothesis
Keywords: CCS; FALS SOD1; Mitochondrial translocation of SOD1 mutants; Macroautophagy; Molecular chaperone; Oxidative stress
Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn)
Keywords: alpha-synuclein; protein aggregation; macroautophagy; proteasome; oxidative stress; Parkinson's disease; CMA; chaperone-mediated autophagy; DOXY; doxycycline; FCS; fetal calf serum; HS; horse serum; LB; Lewy bodies; LDH; lactate dehydrogenase release to l
A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo
Keywords: Thiosemicarbazone; Copper; ER stress; UPR; Macroautophagy; Oxidative stress; Free radicals
Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
Keywords: Alzheimer's disease; Amyloid β; Mitochondria; Oxidative stress; Macroautophagy
Autophagy-mediated antigen processing in CD4+ T cell tolerance and immunity
Keywords: Antigen presentation; T cell selection; Innate immunity; Macroautophagy; Intracellular pathogen; VaccinationMHC, major histocompatibility complex; DC, dendritic cells; APC, antigen presenting cell; TCR, T cell receptor; EBV, Epstein Barr virus; TEC, thymi
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
Keywords: UPS; Macroautophagy; Atg; K48; K63; p62/sequestosome 1; HDAC6; Autophagy; Proteasome
Starvation triggers Aβ42 generation from human umbilical vascular endothelial cells
Keywords: Human umbilical vein endothelial cell; Alzheimer’s disease; Macroautophagy; Starvation; BACE1
Macroautophagy is defective in mucolipin-1-deficient mouse neurons
Keywords: Mucolipidosis type IV; Lysosomal disease; Mucolipin 1; Macroautophagy; Neuronal storage
Ca2+, autophagy and protein degradation: Thrown off balance in neurodegenerative disease
Keywords: Calcium; Macroautophagy; Protein aggregates; Neurons; Mitochondria; ER; Stress; Proteasome; ALS; UPS; Cell death
Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin–proteasome pathways
Keywords: CryAB; HSPB1; Aggregate; Degradation; Solubility; Stability; Proteasome; Macroautophagy
Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells
Keywords: Bafilomycin A1; Macroautophagy; Proliferation; Colon cancer;
Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells
Keywords: Cyclooxygenase-1; Colon cancer; Proliferation; Cell cycle; Macroautophagy
Degradation of neuropathy target esterase by the macroautophagic lysosomal pathway
Keywords: Neuropathy target esterase; Macroautophagy; Lysosome; Degradation
Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP
Keywords: Hypoxia; APP processing; β- and γ-cleavage; Macroautophagy
Quantitative monitoring of autophagic degradation
Keywords: Macroautophagy; Starvation; Kinetics; GFP; Mitochondrial degradation