کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6157057 | 1598242 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Renal Connexome and Possible Roles of Connexins in Kidney Diseases
ترجمه فارسی عنوان
نقش کاننکسینها و نقشهای احتمالی آن در بیماریهای کلیوی
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کلمات کلیدی
connexinsPodocytesSteroid-resistantgap junctions - اتصالات شکاف دارER stress - استرس استdrug research - تحقیقات مواد مخدرmutation - جهشSlit diaphragm - دیافراگم لرزشEndoplasmic reticulum (ER) - رتیکولوم اندوپلاسمی (ER)nephrotic syndrome - سندرم نفروتیکReview - مرورKidney pathology - پاتولوژی کلیهUnfolded protein response (UPR) - پاسخ پروتئین باز شده (UPR)Proteinuria - پروتئینوریCytoskeleton - چارچوب یاخته، سیتواسکلتون، اسکلت سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Connexins are membrane-spanning proteins that allow for the formation of cell-to-cell channels and cell-to-extracellular space hemichannels. Many connexin subtypes are expressed in kidney cells. Some mutations in connexin genes have been linked to various human pathologies, including cardiovascular, neurodegenerative, lung, and skin diseases, but the exact role of connexins in kidney disease remains unclear. Some hypotheses about a connection between genetic mutations, endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in kidney pathology have been explored. The potential relationship of kidney disease to abnormal production of connexin proteins, mutations in their genes together with ER stress, or the UPR is still a matter of debate. In this scenario, it is tantalizing to speculate about a possible role of connexins in the setting of kidney pathologies that are thought to be caused by a deregulated podocyte protein expression, the so-called podocytopathies. In this article, we give examples of the roles of connexins in kidney (patho)physiology and propose avenues for further research concerning connexins, ER stress, and UPR in podocytopathies that may ultimately help refine drug treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 67, Issue 4, April 2016, Pages 677-687
Journal: American Journal of Kidney Diseases - Volume 67, Issue 4, April 2016, Pages 677-687
نویسندگان
Gabriele BPsySc, Salvatore MD, PhD, Claudio MD, Hon FRCP,