کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6161778 | 1249376 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Progranulin protects against renal ischemia/reperfusion injury in mice
ترجمه فارسی عنوان
پروژانولین در مقابل آسیب های ایسکمی / رپرفیوژن کلیوی در موش محافظت می کند
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کلمات کلیدی
آسیب حاد کلیه، هیپوکسی التهاب گیرنده های شناخت الگوی، پروژانولین،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels of PGRN were significantly reduced in the kidney in a mouse model of renal ischemia/reperfusion injury. We also observed that PGRN deficiency (Grnâ/â mice) significantly aggravated renal injury as evidenced by higher serum creatinine, more severe morphological injury, increased tubular epithelial cell death, and tubulointerstitial neutrophil and macrophage infiltration versus wild-type mice. In vitro, we found that recombinant human PGRN attenuated hypoxia-induced inflammatory actions and apoptosis in proximal tubule epithelial cells, at least in part associated with a nucleotide-binding oligomerization domain containing 2 (NOD2)-mediated immune response. Importantly, pretreatment with or delayed administration of recombinant human PGRN protected against or promoted recovery from renal ischemia/reperfusion injury in wild-type and Grnâ/â mice. Similar protective effects were also found in cisplatin-induced AKI. Thus, our findings provide a better understanding of the biological activities of PGRN in the kidney and suggest that PGRN may be an innovative therapeutic strategy for treating patients with AKI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 87, Issue 5, May 2015, Pages 918-929
Journal: Kidney International - Volume 87, Issue 5, May 2015, Pages 918-929
نویسندگان
Meng Zhou, Wei Tang, Yi Fu, Xiaoying Xu, Ziying Wang, Yi Lu, Feng Liu, Xinying Yang, Xinbing Wei, Yan Zhang, Juan Liu, Xue Geng, Chun Zhang, Qiang Wan, Ningjun Li, Fan Yi,