کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6161787 | 1249376 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft
ترجمه فارسی عنوان
امضای ژن مشترک در مطالعات متعدد مربوط به بیومارکرها و تنظیم عملکرد در تحمل به آلوگرافت کلیه است
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کلمات کلیدی
بیومارکر، امضای ژن، متاآنالیز، کلیه متقاطع کلیه، تحمل پیوند
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Patients tolerant to a kidney graft display a specific blood cell transcriptional pattern but results from five different studies were inconsistent, raising the question of relevance for future clinical application. To resolve this, we sought to identify a common gene signature, specific functional and cellular components, and discriminating biomarkers for tolerance following kidney transplantation. A meta-analysis of studies identified a robust gene signature involving proliferation of B and CD4 T cells, and inhibition of CD14 monocyte related functions among 96 tolerant samples. This signature was further supported through a cross-validation approach, yielding 92.5% accuracy independent of the study of origin. Experimental validation, performed on new tolerant samples and using a selection of the top-20 biomarkers, returned 91.7% of good classification. Beyond the confirmation of B-cell involvement, our data also indicated participation of other cell subsets in tolerance. Thus, the use of the top 20 biomarkers, mostly centered on B cells, may provide a common and standardized tool towards personalized medicine for the monitoring of tolerant or low-risk patients among kidney allotransplant recipients. These data point to a global preservation of genes favoring the maintenance of a homeostatic and 'healthy' environment in tolerant patients and may contribute to a better understanding of tolerance maintenance mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 87, Issue 5, May 2015, Pages 984-995
Journal: Kidney International - Volume 87, Issue 5, May 2015, Pages 984-995
نویسندگان
Daniel Baron, Gérard Ramstein, Mélanie Chesneau, Yann Echasseriau, Annaick Pallier, Chloé Paul, Nicolas Degauque, Maria P. Hernandez-Fuentes, Alberto Sanchez-Fueyo, Kenneth A. Newell, Magali Giral, Jean-Paul Soulillou, Rémi Houlgatte, Sophie Brouard,