کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6162934 | 1249410 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
Hyponatremia is the most common electrolyte disorder in clinical practice. Its incidence increases with age and it is associated with increased morbidity and mortality. Recently, the vaptans, antagonists of the arginine vasopressin pathway, have shown promise for safe treatment of hyponatremia. Here we evaluated the efficacy, safety, and tolerability of oral lixivaptan, a selective vasopressin V2-receptor antagonist, for treatment of nonhospitalized individuals with euvolemic hyponatremia (sodium less than 135Â mmol/l) in a multicenter, randomized, double-blind, placebo-controlled, phase III study. About half of the 206 patients were elderly in a chronic care setting. Of these patients, 52 were given a placebo and 154 were given 25-100Â mg per day lixivaptan, titrated based on the daily serum sodium measurements. Compared with placebo (0.8Â mmol/l), the serum sodium concentration significantly increased by 3.2Â mmol/l from baseline to day 7 (primary efficacy endpoint) with lixivaptan treatment. A significantly greater proportion of patients that received lixivaptan achieved normal serum sodium (39.4%) by day 7 relative to placebo (12.2%). Overall, lixivaptan was considered safe and well-tolerated. Thus, oral lixivaptan can be safely initiated in the outpatient setting and effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 82, Issue 11, 1 December 2012, Pages 1215-1222
Journal: Kidney International - Volume 82, Issue 11, 1 December 2012, Pages 1215-1222
نویسندگان
William T. Abraham, Guy Decaux, Richard C. Josiassen, Yoram Yagil, Nelson Kopyt, Hemant P. Thacker, Massimo Mannelli, Daniel G. Bichet, Cesare Orlandi, for the HARMONY Study Group for the HARMONY Study Group,