کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6164531 | 1249474 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population
ترجمه فارسی عنوان
بیماری قلب و عروق زیر بالینی با میزان فیلتراسیون گلومرولی بالا در جمعیت عمومی غیردیابتی همراه است
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کلمات کلیدی
آترواسکلروز، بیماری قلب و عروقی، نرخ فیلتراسیون گلومرولی، بیش از حد فلفل هیپرتروفیک بطن چپ، عوامل خطر،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
A reduced glomerular filtration rate (GFR) in chronic kidney disease is a risk factor for cardiovascular disease. However, evidence indicates that a high GFR may also be a cardiovascular risk factor. This issue remains unresolved due to a lack of longitudinal studies of manifest cardiovascular disease with precise GFR measurements. Here, we performed a cross-sectional study of the relationship between high GFR measured as iohexol clearance and subclinical cardiovascular disease in the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), a representative sample of the middle-aged general population. A total of 1521 persons without cardiovascular disease, chronic kidney disease, diabetes, or micro- or macroalbuminuria were examined with carotid ultrasonography and electrocardiography. The GFR in the highest quartile was associated with an increased odds ratio of having total carotid plaque area greater than the median of non-zero values (odds ratio 1.56, 95% confidence interval 1.02-2.39) or electrocardiographic signs of left ventricular hypertrophy (odds ratio 1.62, 95% confidence interval 1.10-2.38) compared to the lowest quartile. The analyses were adjusted for cardiovascular risk factors, urinary albumin excretion, and fasting serum glucose. Thus, high GFR is associated with carotid atherosclerosis and left ventricular hypertrophy and should be investigated as a possible risk factor for manifest cardiovascular disease in longitudinal studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 86, Issue 1, July 2014, Pages 146-153
Journal: Kidney International - Volume 86, Issue 1, July 2014, Pages 146-153
نویسندگان
Bjørn O. Eriksen, Maja-Lisa Løchen, Kjell A. Arntzen, Geir Bertelsen, Britt-Ann W. Eilertsen, Therese von Hanno, Marit Herder, Trond G. Jenssen, Ulla D. Mathisen, Toralf Melsom, Inger Njølstad, Marit D. Solbu, Ingrid Toft, Ellisiv B. Mathiesen,