کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6188421 | 1600711 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Maternal molecular features and gene profiling of monocytes during first trimester pregnancy Maternal molecular features and gene profiling of monocytes during first trimester pregnancy](/preview/png/6188421.png)
We examined the molecular characteristics of monocytes of pregnant and non-pregnant women to investigate the molecular effects that are associated with immunoregulation at the maternal-fetal interface. We analyzed molecular features and target genes in monocytes of pregnant women using flow cytometry, real-time PCR and oligonucleotide microarray technology. CD14high monocytes and several immune gene members including CD200, CD200R, IDO, IFI27, IL-10 and G0S2 were found to be differentially expressed in monocytes throughout pregnancy. In addition, transcripts within components of the signaling cascade of immune cells (HLA-DRB4, HBEGF, IL-8, CD3D, CCL5), and of several transcription factors (SOCS1, CXCL10, ID1, ID2) were altered in the monocytes of pregnant women. Further studies will be needed to elucidate the biological significance of our observation.
Journal: Journal of Reproductive Immunology - Volume 99, Issues 1â2, September 2013, Pages 62-68