کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196267 1602576 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three-dimensional arrangement of elastic fibers in the human corneal stroma
ترجمه فارسی عنوان
ترتیب سه بعدی الیاف الاستیک در استروما قرنیه انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی


- We have characterised a complex system of elastic fibers in the posterior cornea.
- These exist as sheets in the limbus that fenestrate and become fibers in the cornea.
- We believe these fibers provide the elastic restoring force in the peripheral tissue.
- This system should help explain some surgical properties of the cornea.

The cornea is the main refracting lens in the eye. As part of the outer tunic it has to be resilient, a property conferred by the organisation of the constituent collagen. It also has to be sufficiently elastic to regain its exact shape when deformed, in order not to distort the retinal image. The basis of this elasticity is not fully understood. The purpose of this study was to characterise in three dimensions the arrangement and distribution of elastic fibers in the human corneal stroma, using serial block face scanning electron microscopy. We have demonstrated that there exists a complex network of elastic fibers that appear to originate in the sclera or limbus. These appear as elastic sheets in the limbus and peripheral cornea immediately above the trabecular meshwork which itself appears to extend above Descemet's membrane in the peripheral stroma. From these sheets, elastic fibers extend into the cornea; moving centrally they bifurcate and trifurcate into narrower fibers and are concentrated in the posterior stroma immediately above Descemet's membrane. We contend that elastic sheets will play an important role in the biomechanical deformation and recovery of the peripheral cornea. The network may also have practical implications for understanding the structural basis behind a number of corneal surgeries.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 146, May 2016, Pages 43-53
نویسندگان
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