کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196765 1602594 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron upregulates melanogenesis in cultured retinal pigment epithelial cells
ترجمه فارسی عنوان
آهن در سلول های اپیتلیال رنگدانه های شبکیه سلول های ملانون را تنظیم می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی


- Iron upregulates melanogenesis gene expression.
- Iron increases melanosome number.
- Iron upregulates transcription factors upstream of melanogenesis genes.

The purpose of our studies was to examine the relationship between iron and melanogenesis in retinal pigment epithelial cells, as prior observations had suggested that iron may promote melanogenesis. This relationship has potential clinical importance, as both iron overload and hyperpigmentation are associated with age-related macular degeneration (AMD). Human fetal retinal pigment epithelial cells and ARPE-19 cells were treated with iron in the form of ferric ammonium citrate, after which quantitative RT-PCR and electron microscopy were performed. Melanogenesis genes tyrosinase, tyrosinase-related protein 1, Hermansky-Pudlak Syndrome 3, premelanosome protein and dopachrome tautomerase were upregulated, as was the melanogenesis-controlling transcription factor, microphthalmia-associated transcription factor (MITF). Iron-treated cells had increased pigmentation and melanosome number. Multiple transcription factors upstream of MITF were upregulated by iron.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 128, November 2014, Pages 92-101
نویسندگان
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