Multimodal Therapy for Stage III Retinoblastoma (International Retinoblastoma Staging System)

This study compared the outcomes of VEC chemotherapy with a 5-drug combination of vincristine and carboplatin, alternating with cyclophosphamide, idarubicin, and vincristine, for stage III retinoblastoma. The VEC combination was found to be more effective and may be recommended as neoadjuvant and adjuvant chemotherapy.