کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6210613 1266232 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of a single bout of isometric neuromuscular electrical stimulation on rat gastrocnemius muscle: A combined functional, biochemical and MRI investigation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Effects of a single bout of isometric neuromuscular electrical stimulation on rat gastrocnemius muscle: A combined functional, biochemical and MRI investigation
چکیده انگلیسی

While muscle damage resulting from electrically-induced muscle isometric contractions has been reported in humans, animal studies have failed to illustrate similar deleterious effects and it remains to be determined whether these conflicting results are related to differences regarding experimental procedures or to species. We have investigated in vivo, in rat gastrocnemius muscles, using experimental conditions as close as possible to those used in humans (i.e., muscle length, number of contractions, stimulated muscle), the effects of a single bout of neuromuscular electrical stimulation (NMES). Maximal tetanic force was measured before, immediately after and 1 h and 1, 2, 3, 7 and 14 days after NMES. Magnetic resonance imaging measurements, including volume of gastrocnemius muscles and proton transverse relaxation time (T2) were performed at baseline and 3, 7, and 14 days after the NMES session. Control animals did not perform any exercise and measurements were recorded at the same time points. For both groups, blood creatine kinase (CK) activity was measured within the first 3 days that followed the initial evaluation. Maximal tetanic force decreased immediately after NMES whereas measurements performed 1 h and the days afterwards were similar to the baseline values. CK activity, muscle volume and T2 values were similar throughout the experimental protocol between the two groups. Under carefully controlled experimental conditions, isometric NMES per se did not induce muscle damage in rat gastrocnemius muscles on the contrary to what has been repeatedly reported in humans. Further experiments would then be warranted in order to clearly delineate these differences and to better understand the physiological events associated with muscle damage resulting from NMES-induced isometric contractions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electromyography and Kinesiology - Volume 21, Issue 3, June 2011, Pages 525-532
نویسندگان
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