A study of the physical stability of wet media-milled fenofibrate suspensions using dynamic equilibrium curves

► The concept of dynamic equilibrium in wet media milling is presented. ► Dynamic equilibrium curves were determined using stepwise addition of a stabilizer. ► Synergistic effects between polymer and surfactant have been established. ► An optimal surfactant concentration exists that minimizes growth during storage. ► This optimum is governed by agglomeration and ripening mechanisms.