کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6215246 1271210 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context
چکیده انگلیسی

Gliomas form a heterogeneous group of tumours of the central nervous system. Most gliomas, the so-called 'diffuse gliomas', are characterized by diffuse infiltrative growth in the neuropil. Based on histopathological analysis, diffuse gliomas are subdivided in astrocytic, oligodendroglial, and oligoastrocytic tumours and graded as WHO grade II (low grade), WHO grade III (anaplastic), or WHO grade IV (glioblastoma). Accurate distinction between the different diffuse glioma types and malignancy grades has significant prognostic and therapeutic implications. This review describes essential aspects of the microscopic diagnosis of diffuse gliomas. Because of problems with tissue sampling and imprecise criteria for typing and grading, unequivocal histopathological classification of diffuse gliomas can be challenging. The addition of molecular parameters contributes to a more objective pathological diagnosis of diffuse gliomas. A multidisciplinary approach is mandatory for achieving an optimal diagnosis for patients with these tumours.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 17, Issue 11, November 2011, Pages 486-494
نویسندگان
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