کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
621971 | 882593 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New Fields of Application for Sol-gel Processes: Cold and Vacuum-free ‘Compacting’ of Pharmaceutical Materials to Tablets
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
As new field of application for sol-gel processes the cold and vacuum-free ‘compression’ of pharmaceutical tablets is proposed. Suspensions consisting of an active ingredient, a silica sol and an additive are consolidated by freezing and subsequent drying. Depending on the suspensions composition parameters like porosity and pore size, dissolution behaviour and crushing forces were investigated. Dendrite pore structures were formed as negative images of the former ice crystals in the tablet bodies. An increase of the binder ascorbic acid results in a decreasing porosity, a slower dissolution velocity but an increasing crushing force.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 85, Issue 7, 2007, Pages 1013–1019
Journal: Chemical Engineering Research and Design - Volume 85, Issue 7, 2007, Pages 1013–1019
نویسندگان
N. Pachulski, J. Ulrich,