کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6230181 1608127 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Variability in the substance use disorder exclusion criterion in antidepressant efficacy trials
ترجمه فارسی عنوان
متغیر بودن معیار خروج از اختلالات مصرف مواد در آزمایشات اثربخشی ضد افسردگی
کلمات کلیدی
معیارهای خروج، آزمایشات اثربخشی ضد افسردگی، اعتبار خارجی، داروهای ضد افسردگی، عمومی بودن، اختلال مصرف مواد اختلال مصرف الکل، اختلال مصرف مواد مخدر، اختلال افسردگی عمده،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Substance use disorders are the most commonly excluded psychiatric disorder in antidepressant efficacy trials (AETs).
- Studies varied in which disorders formed the basis of exclusion (abuse or dependence; alcohol or illicit drugs or both).
- The time frame had a greater impact on the number of patients who would be excluded than the abuse/dependence distinction.
- The definition of the substance use exclusion was the same in studies of the past 5 years compared to the prior 15 years.

BackgroundSubstance use disorders are the most commonly excluded psychiatric disorder in antidepressant efficacy trials (AETs). In a recent review of AETs we noticed variability in the definition of the substance use disorder exclusion criterion. In the present report we examined in greater detail the variability in defining the substance use disorder exclusion criterion, the potential impact of this variability on excluding patients from an AET, and whether the definition of the criterion has changed in the past 20 years.MethodsWe identified 170 AETs published during the past 20 years and compared the studies published during the past 5 years (n=56) to the studies published during the 15 prior years (n=114).ResultsSubstance abuse was more frequently used as an exclusion criterion than substance dependence. Six time frames have been used as the basis of exclusion, the most frequent being the past 12 months. The time frame had a greater impact on the number of patients who would be excluded than the abuse/dependence distinction. The definition of the substance use exclusion criterion was no different in the studies of the past 5 years compared to the prior 15 years.LimitationsA limitation of the present analysis is that it was based on published placebo-controlled studies of antidepressants.ConclusionStudies varied in whether abuse or dependence was the basis of exclusion, whether alcohol or illicit drugs or both were the basis of exclusion, and the time frame of the disorders' presence. We raise the question of whether the routine exclusion of patients with a substance use disorder should be reflected in a product's label.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 198, 1 July 2016, Pages 39-42
نویسندگان
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