کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6232636 1608158 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary communicationAnterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: A potential new tool for diagnosis
ترجمه فارسی عنوان
ارتباط مقدماتی سطح کولین قارچ سینگولت در نوجوانان زن با افسردگی یکپارچه در مقابل دوقطبی: یک ابزار بالقوه جدید برای تشخیص
کلمات کلیدی
تصویر برداری عصبی، دو قطبی، یکپارچه، بیومارکر، تشخیص، طیف سنجی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundDelayed diagnosis in bipolar disorder (BD) due to misdiagnosis as major depressive disorder (MDD) is a significant public health concern. Thus, identification of relevant diagnostic biomarkers is a critical unmet need, particularly early in the course of illness. The anterior cingulate cortex (ACC) is thought to play an important role in mood disorder pathophysiology. Case-control studies utilizing proton-1 magnetic resonance spectroscopy (1H-MRS) have found increased total choline levels in several brain regions in MDD. However, there are no published 1H-MRS reports directly comparing adolescents with MDD and BD. We hypothesized that ACC choline levels would be increased in adolescents with unipolar versus bipolar depression.MethodsWe studied depressed adolescents with MDD (n=28; mean age 17.0±2.1 years) and BD (n=9; 17.3±3.1 years). A Siemens Verio 3-Tesla clinical MRI system was used to acquire scans, using a single-voxel PRESS sequence. The voxel (18.75 cm3) was positioned on the ACC in the midsagittal plane. To remove potential gender effects, only female adolescent participants were included. Data were analyzed using the ANOVA and post-hoc Tukey tests.ResultsA significantly increased ACC choline/creatine ratio was observed in participants with MDD (mean=0.253±0.021) compared to BD (mean=0.219±0.020) (p=0.0002). There were no significant differences in the other 1H-MRS metabolites.LimitationsCross sectional design, single gender sample, limited sample size.ConclusionsThe present findings suggest that ACC total choline may have the potential to serve as a diagnostic biomarker in adolescent mood disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 167, 1 October 2014, Pages 25-29
نویسندگان
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