The DRD2 rs1800497 polymorphism increase the risk of mood disorder: Evidence from an update meta-analysis

BackgroundGrowing studies have revealed the association between rs1800497 polymorphism in the dopamine receptor D2 (DRD2) and susceptibility to mood disorder (MD). However, the results remained inconsistent.MethodsTo assess the effect of DRD2 rs1800497 polymorphism on MD. We performed a meta-analysis based on eight case-control studies, including a total of 2097 MD cases and 1681 controls. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for DRD2 rs1800497 polymorphism and MD risk were estimated.ResultsOur meta-analysis indicated that DRD2 rs1800497 was associated with an increased MD risk, especially in Asians. Moreover, in the subgroup analysis by the type of MD, DRD2 rs1800497 polymorphism was observed to increase risk in BP.LimitationsThe results should be treated with caution for lacking of data to perform gene-gene and gene-environment interaction.ConclusionsOur results indicated that polymorphism in DRD2 rs1800497 may play a role in development of MD.