کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6234134 1277556 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewAssociation between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: A meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
ReviewAssociation between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: A meta-analysis
چکیده انگلیسی

BackgroundPrevious studies have implicated norepinephrine transporter (NET) gene polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide NET polymorphisms, T-182C (rs2242446) in the promoter region and G1287A (rs5569) in exon 9, were found to be associated with MDD in different populations. However, inconsistent and inconclusive results have also been obtained.MethodsIn this study, we examined whether rs2242446 and rs5569 genetic variants are related to the etiology of MDD using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria.ResultsEight articles were identified that tested the relationship between the NET T-182C and/or G1287A polymorphism and MDD. Statistical analyses revealed no significant association between these polymorphisms and MDD (OR=1.23, 95% CI=0.77−1.97, P=0.38 for T-182C; OR=1.00, 95% CI=0.78−1.29, P=0.99 for G1287A).LimitationsThe results must be treated with caution because of the small sample sizes of several included studies.ConclusionsOur findings suggest that the NET T-182C and G1287A polymorphisms are not susceptibility factors for MDD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 150, Issue 1, 15 August 2013, Pages 23-28
نویسندگان
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