کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6234923 1608176 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A double-blind, randomized, placebo-controlled trial of adjunctive ramelteon for the treatment of insomnia and mood stability in patients with euthymic bipolar disorder
ترجمه فارسی عنوان
یک آزمایش دو سوکور، تصادفی و کنترل شده با کنترل دارونما از داروی راملتون برای درمان بیخوابی و استحکام خلق در بیماران مبتلا به اختلال دوقطبی یوتومی
کلمات کلیدی
اختلال دو قطبی، ریتم شبانه روزی، راملئتون، ملاتونین، یوتیمیا،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundAbnormalities in circadian rhythms are prominent features of bipolar disorder. Disrupted circadian rhythms are associated with an increased risk of relapse in bipolar disorder. Normalizing the circadian rhythm pattern of bipolar patients may improve their sleep and lead to fewer mood exacerbations. This study evaluated adjunctive ramelteon for the treatment of insomnia and mood stability in euthymic bipolar patients.MethodsParticipants with euthymic bipolar disorder and sleep disturbances were randomized to receive adjunctive ramelteon or placebo in addition to their regular psychiatric medications for up to 24 weeks or until they experienced a relapse (defined as a depressed or manic event).Results83 participants were randomized to receive ramelteon (n=42) or placebo (n=41). Forty participants relapsed (48.2%). Cox regression analyses indicated that participants who received ramelteon (odds ratio 0.48, p=.024) were less likely to relapse. Kaplan Meier curves also indicated longer median survival times in the ramelteon group (Mdn=188 days) versus the placebo group (Mdn=84 days) X2(1)=5.33, p=.02. There were no serious adverse events in this study.LimitationsThis was a small study with only 83 participants. The one-week window of confirmed stability is shorter than time intervals used in other studies.ConclusionsThe present study shows that ramelteon was effective in maintaining stability for individuals with bipolar disorder. Patients treated with ramelteon were approximately half as likely to relapse as patients treated with placebo throughout the 24-week treatment period.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 144, Issues 1–2, 10 January 2013, Pages 141-147
نویسندگان
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