کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6235301 1608182 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low trait anxiety, high resilience, and their interaction as possible predictors for treatment response in patients with depression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Low trait anxiety, high resilience, and their interaction as possible predictors for treatment response in patients with depression
چکیده انگلیسی

BackgroundAlthough many demographic and clinical characteristics have been suggested to predict treatment outcome of depression, they provide only a weak prediction for clinical response. Based on the predictive values of trauma and biological markers involved in stress response, we investigated the roles of baseline trait anxiety and resilience, which were assumed as vulnerability and resilience factors, respectively, in predicting treatment response in naturalistically treated outpatients with depressive disorders.MethodsA total of 178 outpatients with depressive disorders were consecutively recruited and completed measures of trauma experiences, psychological symptoms, and resilience at baseline. Response was defined by Clinical Global Impression (CGI)-Improvement score ≤ 2 at last visit during a 6 month-treatment period. Univariate analyses and multiple logistic regression analysis were performed to determine predictors of treatment response.ResultsAmong demographic and clinical variables, treatment response was associated with increased age, longer treatment duration, higher resilience, and lower trait anxiety. In logistic regression analysis, resilience, trait anxiety, and their interaction significantly predicted treatment response after adjusting for age and treatment duration. Interaction between resilience and trait anxiety remained significant in the final model. Examining the interaction between the two, patients with low trait anxiety were only significantly affected by the level of resilience in response rate.ConclusionsLow trait anxiety, high resilience, and their interaction might contribute to better treatment response in depressed patients. Our result suggested that individual differences in responding to stress might be important in predicting treatment outcome of depression in addition to other demographic and clinical factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 137, Issues 1–3, March 2012, Pages 61-69
نویسندگان
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