کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6235333 1608182 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers
چکیده انگلیسی

BackgroundDespite the old Kraepelinean concept that bipolar disorder (BD) does not evolve with cognitive decline, the presence of cognitive impairment, especially executive dysfunction has been recognized in BD patients. Brain-derived neurotrophic factor (BDNF) and pro-inflammatory molecules are important contributors to the pathophysiology of BD, and imbalance in peripheral levels of these molecules may be implicated in the cognitive decline observed in BD patients. We aimed to investigate the executive performance of BD type I euthymic patients and its relation with the plasma levels of BDNF, TNF-α and its related soluble receptors (sTNFR1 and sTNFR2).MethodsWe evaluated executive functioning through the Frontal Assessment Battery (FAB). Plasma levels of BDNF, TNF-α, sTNFR1 and sTNFR2 were measured using enzyme-linked immunosorbent assay (ELISA) in 25 euthymic type I BD patients and 25 age and gender matched healthy controls.ResultsBD patients had an impairment in executive functioning (p < 0.006), particularly sensitivity of interference (p = 0.02), inhibitory control (p = 0.02), and increased BDNF plasma levels (p = 0.001) in comparison with controls. Plasma levels of TNF-α were correlated with inhibitory control in BD patients (ρ = 0.50, p = 0.02) while motor programming was negatively correlated with sTNFR2 plasma levels (ρ = − 0.47, p = 0.02) in controls. Executive function correlated with age and MMSE, but not with BDNF, neither was influenced by psychiatric and clinical comorbidities nor medications in use.ConclusionBDNF is altered in BD but do not correlate with executive functioning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 137, Issues 1–3, March 2012, Pages 151-155
نویسندگان
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