کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6235493 1277587 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Negative affectivity moderated by BDNF and stress response
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Negative affectivity moderated by BDNF and stress response
چکیده انگلیسی

BackgroundGene × environment (G × E) interactions are known to predict susceptibility to disorders such as depression and anxiety. Adverse experiences in childhood and number of stressful life events (SLEs) have been widely studied as environmental risk factors; however, SLE response has not yet been studied. Here we present a first attempt at the analysis of the interaction between the response to personal and academic stressful events during different life stages and the gene polymorphisms 5-HTTLPR, 5-HTTVNTR (STin2), HTR1A C(− 1019)G, and BDNF Val66Met in the prediction of negative affectivity (NA).MethodsStandardized questionnaires (ST-DEP and STAI) were used to measure negative affectivity derived from depression and anxiety in a sample of 303 undergraduate students. Response to stressful events during childhood, high school and college years was evaluated together with a self-report personal history form. Multiple logistic regression analysis was used to perform association and G × E analysis.ResultsNegative affectivity is strongly associated with childhood maltreatment and stress response. Gene associations were observed between 5-HTTVNTR allele 12 and the S_12 haplotype with NA derived from high scores in both depression and anxiety. The BDNF gene variant was not associated with NA derived from depression or anxiety alone, but it was associated with the comorbid presentation. A significant G × E interaction was observed between the BDNF Val66Met and stress response during childhood and college years although the risk for negative affectivity conferred by stress response during childhood was only significant among the Met allele carriers, while stress response during college years was a significant risk factor regardless of the BDNF Val66Met genotype. A significant G × E interaction was also found between the HTR1A C(− 1019)G variant and childhood maltreatment.LimitationsThe study has two main limitations, sample size is low and retrospective recognition of SLEs is a concern.ConclusionAltogether, our results demonstrate that the BDNF Val66Met variant moderates the effect of stress during both childhood and college years; although this effect seems to be more critical during childhood given that the risk conferred by childhood stress was restricted to the Met allele carriers. We also found that the HTR1A C(− 1019)G variant moderates the effect of childhood maltreatment in our study population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 136, Issue 3, February 2012, Pages 767-774
نویسندگان
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