کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6236219 | 1608190 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Predictors of response to ultrabrief right unilateral electroconvulsive therapy Predictors of response to ultrabrief right unilateral electroconvulsive therapy](/preview/png/6236219.png)
BackgroundRecent trials have demonstrated clinically meaningful efficacy and minimal cognitive side effects with ultrabrief pulsewidth right unilateral (RUL) ECT. In many countries it is gradually being adopted into clinical practice and further information on predictors of response is needed.MethodsData collected from 75 depressed patients who received ultrabrief RUL ECT in a prospective research trial were analysed for predictors of response. Mood improvement was assessed with the Montgomery-Asberg Depression Rating Scale. Improvement in unipolar versus bipolar depression was analysed.ResultsSixty-one percent of patients met the criteria for response and 36% met the criteria for remission. Logistic regression identified index episode duration â¥Â one year (OR = 10.50, p = .006), fewer failed antidepressant treatments (OR = 0.46, p = .003), previous ECT course (OR = 7.33, p = .01), and absence of concurrent antidepressant (OR = 0.09, p = .005) as predictors of response. Psychotic features (OR = 7.18, p = .032) and baseline depression severity (OR = 0.90, p = .017) were predictors of remission. There was a trend towards greater improvement in bipolar than unipolar depression in the first week of treatment (p = 0.077).LimitationsData were obtained from a prospective but non-randomised clinical trial which was designed to evaluate efficacy rather than to examine predictors of response. Treatment decisions (concurrent medication, switching to other types of ECT) were made on clinical grounds.ConclusionsThis preliminary study suggests that predictors of response for ultrabrief RUL ECT are similar to those identified for other types of ECT previously studied.
Journal: Journal of Affective Disorders - Volume 130, Issues 1â2, April 2011, Pages 192-197