کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6236756 1608205 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression
چکیده انگلیسی

BackgroundBrain-derived neurotrophic factor (BDNF) is putatively involved in the pathophysiology of depression. This study examined associations between BDNF genotype at the Val66Met locus, depression symptoms, and serum BDNF levels.MethodsTwenty-eight subjects in the primary study (25 female, 3 male) completed diagnostic interviews, self-report questionnaires, and provided blood samples for serum BDNF quantification and buccal cell samples for genotyping. Data from a second sample of 189 subjects (94 female, 95 male) were also analyzed.ResultsThe Val/Val genotype was associated with higher scores on the Cognitive-Affective factor of the Beck Depression Inventory-II (BDI-II) in the primary sample. No evidence was found for association between genotype and serum BDNF in this sample. Consistent with the primary study, Val/Val genotype was associated with higher total BDI-II scores, Cognitive-Affective factor scores, and Somatic-Vegetative factor scores, in the second sample. Serum BDNF measures were not available for the second sample.LimitationsThe mechanism through which BDNF genotype translates into (putative) differences in depression symptoms is not known.ConclusionsIn contrast to case-control association studies, we demonstrate two changes in the operationalization of the phenotype. Additionally, we found an association between Val/Val genotype and higher levels of depression symptoms. This result is distinct from an association between BDNF genotype and diagnosis of depression, and it may help to clarify our understanding of genetic liability to depression, which will ultimately lead to more nuanced and effective treatment strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 115, Issues 1–2, May 2009, Pages 215-219
نویسندگان
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