کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6236858 | 1608214 | 2008 | 5 صفحه PDF | دانلود رایگان |

BackgroundSerotonin (5-HT) has been implicated in the pathophysiology of several psychiatric disorders including major depression (MD). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), and might be related to the pathogenesis of MD. Two isoforms are known, TPH-1 and TPH-2. Their association with MD is still debated.MethodsA case-control design was used for candidate gene-disease association in 194 patients with stress-induced MD, and 246 healthy controls, all North European Caucasians. Five TPH-2 polymorphisms were analyzed in terms of genotype, allele, and haplotype-based associations.ResultsNeither single marker nor haplotype-based analyses showed significant associations between TPH-2 and MD.LimitationsThe interpretations are limited by the restricted population size.ConclusionsThere was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. Hence, the results suggest that in this particular group of stress-induced depression patients TPH-1 appears to be more relevant to MD pathogenesis than TPH-2.
Journal: Journal of Affective Disorders - Volume 107, Issues 1â3, April 2008, Pages 175-179