Characterization of VEGF and Angiopoietins Expression in Human Corpus Cavernosum during Aging

Immunoflourescent studies of cellular markers and growth factors help clarifying vascular organization and angiogenesis mechanisms in erectile tissue. Our findings demonstrate that the organization pattern of vascular endothelium and smooth muscle components of cavernosal tissue modifies during aging. Ang1 and Ang2 upregulation in human-aged penile tissue suggest a VEGF-independent vascular remodeling mechanism. Tomada N, Tomada I, Cruz F, Vendeira P, and Neves D. Characterization of VEGF and angiopoietins expression in human corpus cavernosum during aging.