کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6251848 1611983 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original researchYttrium-90 radioembolization is a safe and effective treatment for unresectable hepatocellular carcinoma: A single centre experience of 45 consecutive patients
ترجمه فارسی عنوان
تحقیقات اصلی رادیو آمبولیزه ییتیوم 90 یک درمان ایمن و موثر برای کارسینوم های غیر قابل توصیف سلول های سرطانی می باشد: یک تجربه تک مرکز از 45 بیمار متوالی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Forty-five patients underwent resin-based 90Y radioembolization for unresectable HCC between 2006 and 2013.
- Median survival was excellent at 27.7 months; 3 year survival was 26%.
- Of the 40 patients, a complete/partial radiological response to treatment was observed in 19 (48%) patients.
- A good radiological response to treatment was associated with improved survival.
- Thirteen (29%) patients developed clinical toxicity after treatment; all complications were minor (grade I/II).

Introduction: There is controversy regarding the role of yttrium-90 (90Y) radioembolization in the management of advanced, unresectable hepatocellular carcinoma (HCC). Methods: Forty-five consecutive patients underwent resin-based 90Y radioembolization for unresectable, HCC between 2006 and 2013 in Sydney, Australia. All patients were followed up with imaging studies at regular intervals until death. Radiologic response was evaluated with the Response Criteria in Solid Tumors (RECIST) criteria. Clinical toxicities were prospectively recorded. Survival was calculated by the Kaplan-Meier method and potential prognostic variables were identified on univariate and multivariate analysis. Results: Follow-up in the complete cohort was 7.8 (range, 0.1-41.8) months. The median survival after 90Y radioembolization was 27.7 months with a 36-month survival of 26%. By RECIST criteria of the 40 patients followed-up beyond 2 months, a complete response (CR) to treatment was observed in 1 patients (3%), partial response (PR) in 18 (45%), stable disease (SD) in 11 (22%) and progressive disease (PD) in 10 (25%). On multivariate analysis only radiological response to treatment was independently associated with improved survival: CR/PR to treatment vs. SD vs. PD; p < 0.001. Thirteen patients (29%) developed clinical toxicity after treatment; all complications were minor (grade I/II) and resolved without active intervention. Conclusion: Radioembolization with 90Y is a safe and effective treatment for unresectable HCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 12, Issue 12, December 2014, Pages 1403-1408
نویسندگان
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