کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6253842 1288410 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncology/endocrineAssociation between telomerase reverse transcriptase rs2736100 polymorphism and risk of glioma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Oncology/endocrineAssociation between telomerase reverse transcriptase rs2736100 polymorphism and risk of glioma
چکیده انگلیسی

BackgroundEpidemiological studies have been conducted to investigate the association of telomerase reverse transcriptase (TERT) rs2736100 polymorphism with glioma risk. The aim of the present study was to evaluate the association of TERT rs2736100 polymorphism with glioma risk using a meta-analysis approach.Materials and methodsAll eligible studies were identified through a search of PubMed, EMBASE, China National Knowledge Infrastructure, Database of Chinese Scientific and Technical Periodicals, and China Biology Medical literature database before January 2014. The association between the TERT rs2736100 polymorphism and glioma risk was estimated by odds ratio (OR) and 95% confidence interval (CI).ResultsA total of nine case-control studies including 9411 cases and 13,708 controls were eventually collected. Overall, we found that TERT rs2736100 polymorphism was significantly associated with the risk of glioma (OR = 1.29, 95% CI 1.24-1.34, P < 0.001). In the subgroup analysis based on ethnicity, the significant association was found in Caucasians (OR = 1.29, 95% CI 1.24-1.34, P < 0.001). In subgroup analyses by histology, the associations were significant in glioblastoma (OR = 1.45, 95% CI 1.32-1.60, P < 0.001), astrocytoma (OR = 1.41, 95% CI 1.26-1.58, P < 0.001), and oligodendroglioma (OR = 1.20, 95% CI 1.05-1.37, P = 0.008).ConclusionsTaken together, these data suggested that TERT rs2736100 polymorphism may contribute to glioma susceptibility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 191, Issue 1, September 2014, Pages 156-160
نویسندگان
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