کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6254035 | 1288418 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: CardiothoracicImproved cardioprotection using a novel stepwise ischemic preconditioning protocol in rabbit heart CardiothoracicImproved cardioprotection using a novel stepwise ischemic preconditioning protocol in rabbit heart](/preview/png/6254035.png)
BackgroundThe current commonly used cardiac ischemic preconditioning (IPC) protocol, involving three 5-min cycles of ischemia-reperfusion (I/R), may not be clinically beneficial because of its acutely deleterious effects on hemodynamics. This study attempted to assess the effects of a novel stepwise IPC scheme on cardiac function, infarct size, and arrhythmogenesis in a rabbit model of prolonged I/R.MethodsAnesthetized open-chest rabbits were subjected to 60-min occlusion of a proximal branch of the left coronary artery followed by 180-min reperfusion. Animals were divided into five groups (n = 6 each): (1) control group (no IPC); (2) 2-min IPC group (three cycles of 2-min IPC); (3) 5-min IPC group (three cycles of 5-min IPC); (4) 10-min IPC group (three cycles of 10-min IPC); and (5) stepwise IPC group (2-, 5-, and 10-min I/R).ResultsCompared with control group, 2-, 5-, and 10-min IPC decreased arrhythmia score by 16%, 67%, and 33%, respectively. Remarkably, stepwise IPC resulted in a 78% reduction of arrhythmias. Stepwise IPC also produced the least ventricular infarct size when compared with 2-, 5-, and 10-min IPC groups (16.4% versus 39.3%, 28.1%, and 38.5%, P < 0.05).ConclusionsThese results suggest that stepwise IPC has better cardioprotective effects against prolonged I/R injury and may serve as an acceptable approach to clinical revascularization procedures on the heart, including catheter-based and surgical approaches.
Journal: Journal of Surgical Research - Volume 188, Issue 2, 15 May 2014, Pages 381-386