کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6256312 | 1289914 | 2016 | 10 صفحه PDF | دانلود رایگان |
- We compared the behaviour of NK1Râ/â mice and wildtypes in the 5-Choice Continuous Performance Test.
- NK1Râ/â mice did not express excess impulsivity (premature response or false alarms) in this test.
- NK1Râ/â mice expressed excessive perseveration, which is common in ADHD.
- The findings point to a behavioural phenotype for ADHD patients with polymorphism of the TACR1 gene.
Mice lacking functional NK1 (substance P-preferring) receptors typically display excessive inattentiveness (omission errors) and impulsivity (premature responses) when compared with wildtypes in the 5-Choice Serial Reaction-Time Test (5-CSRTT). These abnormal behaviours are analogous to those seen in humans suffering from Attention Deficit Hyperactivity Disorder (ADHD). Here we used the 5-Choice ContinuousâPerformance Test (5C-CPT) to ascertain whether NK1Râ/â mice also display excessive false alarms (an inappropriate response to a 'no-go' signal), which is another form of impulsive behaviour. NK1Râ/â mice completed more trials than wildtypes, confirming their ability to learn and carry out the task. At the start of Stage 1 of training, but not subsequently, they also scored more premature responses than wildtypes. When the mice were tested for the first time, neither false alarms nor premature responses was higher in NK1Râ/â mice than wildtypes but, as in the 5-CSRTT, the latter behaviour was strongly dependent on time of day. NK1Râ/â mice expressed excessive perseveration during all stages of the 5C-CPT. This behaviour is thought to reflect compulsive checking, which is common in ADHD patients. These findings point to differences in the 5-CSRTT and 5C-CPT protocols that could be important for distinguishing why the cognitive performance and response control of NK1Râ/â mice differs from their wildtypes. The results further lead to the prediction that ADHD patients with polymorphism of the TACR1 gene (the human equivalent of Nk1r) would express more perseveration, but not false alarms, in Continuous Performance Tests when compared with other groups of subjects.
Journal: Behavioural Brain Research - Volume 298, Part B, 1 February 2016, Pages 268-277