Keywords: گیرنده NK1; Translational model; Hyperalgesia; Substance P; Arthritic pain; Disease modeling; NK1 receptor;
مقالات ISI گیرنده NK1 (ترجمه نشده)
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Keywords: گیرنده NK1; Substance P; NK1 receptor; Hyperalgesia; Inflammatory pain; Neuropathic pain; Trigeminal nerve;
Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P
Keywords: گیرنده NK1; Substance P; NK1 receptor; NK2 receptor; Breast cancer; Metastasis; MIP-2;
Behavioral sensitization induced by dorsal periaqueductal gray electrical stimulation is counteracted by NK1 receptor antagonism in the ventral hippocampus and central nucleus of the amygdala
Keywords: گیرنده NK1; Dorsal periaqueductal gray; Ventral hippocampus; Amygdala; Elevated plus maze; NK1 receptor; Posttraumatic stress disorder;
The potential role of substance P in brainstem homeostatic control in the pathogenesis of sudden infant death syndrome (SIDS)
Keywords: گیرنده NK1; Sudden infant death syndrome; Substance P; NK1 receptor; Serotonin; Medulla oblongata; Brainstem; Neurotransmitter;
Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial
Keywords: گیرنده NK1; chronic pruritus; itch; neurokinin 1 receptor; NK1 receptor; NK1 receptor antagonist; serlopitant; substance P; DLQI; Dermatology Life Quality Index; e-diary; electronic diary; NK1R; neurokinin 1 receptor; NRS; numeric rating scale; PGA; Physician's Globa
Cross-talk between 5-hydroxytryptamine and substance P in the melanogensis and apoptosis of B16F10 melanoma cells
Keywords: گیرنده NK1; 5-HT; SP; Cross-talk; 5-HT2A receptor; NK1 receptor; Melanogenesis
Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor
Keywords: گیرنده NK1; Binding kinetics; NK1 receptor; Label-free; Association rate; GPCR; Tachykinin;
Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis
Keywords: گیرنده NK1; Osteoporosis; Substance P; NK1 receptor; Bone remodeling; Ovariectomy;
Research reportDifferences in the performance of NK1Râ/â ('knockout') and wildtype mice in the 5âChoice Continuous Performance Test
Keywords: گیرنده NK1; ADHD; False alarms; Inattentiveness; NK1 receptor; Perseveration; Premature responses; 5-Choice Continuous-Performance Test; Impulsivity; Motor disinhibition;
News and reviewsRole of substance P in the cardiovascular system
Keywords: گیرنده NK1; Substance P; NK1 receptor; Cardiovascular regulation; Antagonist;
Dorsal periaqueductal gray post-stimulation freezing is counteracted by neurokinin-1 receptor antagonism in the central nucleus of the amygdala in rats
Keywords: گیرنده NK1; ANOVA; analysis of variance; SP; Substance P; SPA; spantide; dPAG; dorsal periaqueductal gray matter; BLA; basolateral nucleus of the amygdala; MeA; medial nucleus of the amygdala; CeA; central nucleus of the amygdala; EPM; elevated plus maze; ES; electri
In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant
Keywords: گیرنده NK1; Pronetupitant; Netupitant; NK1 receptor; Calcium mobilization; Guinea pig ileum; SBL test
Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation
Keywords: گیرنده NK1; Cisplatin; Emesis; NK1 receptor; 5-HT3 receptor; ERK1/2; PKA;
Research reportNK1 receptors antagonism of dorsal hippocampus counteract the anxiogenic-like effects induced by pilocarpine in non-convulsive Wistar rats
Keywords: گیرنده NK1; Pilocarpine; Anxiety; NK1 receptor; Dorsal hippocampus; Lateral septum; Elevated plus-maze;
Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva)
Keywords: گیرنده NK1; Cyclophosphamide; Emesis; Least shrew; Immediate; Delayed; Brainstem; Intestine; NK1 receptor; 5-HT3 receptor; Substance P; PKA; ERK1/2; cAMP
Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva)
Keywords: گیرنده NK1; Least shrew; Emesis; L-type calcium channel; 5-HT3 receptor; D2 receptor; NK1 receptor; M1 receptor; FPL 64176; Nifedipine; Palonosetron; 2-Me-5-HT; Apomorphine; Quinpirole; McN-A-343; Cisplatin
Molecular mechanisms of 5-HT3 and NK1 receptor antagonists in prevention of emesis
Keywords: گیرنده NK1; Ondansetron; Granisetron; Dolasetron; Tropisetron; Palonosetron; Aprepitant; Netupitant; 5-HT3 receptor; NK1 receptor
Cisplatin causes over-expression of tachykinin NK1 receptors and increases ERK1/2- and PKAâ phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem
Keywords: گیرنده NK1; Least shrew; Cisplatin; Emesis; Immediate; Delayed; Brainstem; Intestine; NK1 receptor; 5-HT3 receptor; Substance P; ERK1/2; PKA Intestine;
Age, sex and NK1 receptors in the human brain - A positron emission tomography study with [11C]GR205171
Keywords: گیرنده NK1; Age; Sex; NK1 receptor; Substance P; Positron emission tomography;
Pharmacological mechanisms of 5-HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting
Keywords: گیرنده NK1; Palonosetron; Ondansetron; Granisetron; Netupitant; 5-HT3 receptor; NK1 receptor;
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain
Keywords: گیرنده NK1; NK1 receptor; Supraspinal level; Naloxone; Hyperalgesia; Allodynia; Inflammatory pain
Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction
Keywords: گیرنده NK1; Tachykinin; NK1 receptor; 3-Phenylpiperidine-4-carboxamide;
Subpopulations of neurokinin 1 receptor-expressing neurons in the rat lateral amygdala display a differential pattern of innervation from distinct glutamatergic afferents
Keywords: گیرنده NK1; NK1 receptor; amygdala; interneuron; glutamate; parvalbumin; BA; basal nucleus of the amygdala; BLA; basolateral complex of the amygdala; BP; band pass; CaMKIIα; calcium/calmodulin kinase IIα; CB; calbindin-D28K; CBP; calcium binding protein; CR; calret
Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine
Keywords: گیرنده NK1; Glial cell; Histamine; Nociception; NMDA receptor; NK1 receptor; Spinal cord;
Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva)
Keywords: گیرنده NK1; 5-HT3 receptor; NK1 receptor; 2-methyl 5-HT; GR73632; Synergistic; Emesis; Least shrew; Cross-talk; Interaction;
Fos expression induced by activation of NMDA and neurokinin-1 receptors in the trigeminal subnucleus caudalis in vitro: Role of protein kinases
Keywords: گیرنده NK1; Vc, trigeminal subnucleus caudalis; Vi, trigeminal subnucleus interpolaris; TTX, tetrodotoxin; Sar9, [Sar9,Met(O2)11]-SP; ChCl, chelerythrine chlorideFos; Trigeminal system; PKA; PKC; NK1 receptor; NMDA receptor
Role of tachykinin receptors in the modulation of colonic peristaltic activity in mice
Keywords: گیرنده NK1; NK1 receptor; NK2 receptor; NK3 receptor; Tachykinins; Colon; Peristalsis
Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis
Keywords: گیرنده NK1; NK1 receptor; G93A transgenic mouse; Non NMDA receptors; Electrophysiology;
Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety
Keywords: گیرنده NK1; NK1 receptor; Synthesis; RadiolabellingCNDCKVKAMQTYNU-UHFFFAOYSA-N; WTDKJBUIASFIOD-UHFFFAOYSA-N; XXJGPEJPJHNGJF-UHFFFAOYSA-N; SOVZPUNJPSNXQR-UHFFFAOYSA-N; QCVSZRBCNKHMIP-UHFFFAOYSA-N; FUCPKVYRKXXLFP-UHFFFAOYSA-N; QTBWRBOKUGQAPL-UHFFFAOYSA-N; GVBGRESFEXAWS
Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists
Keywords: گیرنده NK1; Tachykinin; NK1 receptor; 3-Phenyl-4-benzylaminopiperidine; Asymmetric synthesis; Dynamic kinetic resolution;
Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference
Keywords: گیرنده NK1; Substance P; NK1 receptor; Globus pallidus; Conditioned place preference; Reward
Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks
Keywords: گیرنده NK1; XBXT; Xiao-Ban-Xia-Tang; 5-HT; 5-hydroxytryptamine; SP; substance P; NK1-R; Neurokinin-1 receptor; Xiao-Ban-Xia-Tang; Vomiting; Mink; Cisplatin; NK1 receptor;
Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
Keywords: گیرنده NK1; dorsal horn; pain; NK1 receptor; CGRP; VGLUT2; glutamatergic synapse; AMPAr; AMPA, receptor; CGRP; calcitonin gene-related peptide; LPb; lateral parabrachial area; LTP; long-term potentiation; NK1r; neurokinin 1 receptor; pERK; phosphorylated extracellula
Decreased Neurokinin-1 (Substance P) Receptor Binding in Patients with Panic Disorder: Positron Emission Tomographic Study with [18F]SPA-RQ
Keywords: گیرنده NK1; NK1 receptor; panic attack; panic disorder; positron emission tomography (PET); substance P
The involvement of substance P in the induction of aggressive behavior
Keywords: گیرنده NK1; Substance P; NK1 receptor; Aggression; Defensive rage; Aggressive attack; Medial amygdaloid nucleus; Medial and lateral hypothalamus; Periaqueductal grey
Spinal ERK activation via NO–cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide
Keywords: گیرنده NK1; Morphine-3-glucuronide (M3G); NK1 receptor; NMDA receptor; Nitric oxide (NO)–cGMP–PKG pathway; Extracellular signal-regulated kinase (ERK); Dorsal spinal cord; Mice
Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: A model of attention deficit hyperactivity disorder
Keywords: گیرنده NK1; Attention deficit hyperactivity disorder (ADHD); Hyperactivity; Microdialysis; Monoamine; NK1 receptor; Psychostimulant
NK1 receptor-expressing spinoparabrachial neurons trigger diffuse noxious inhibitory controls through lateral parabrachial activation in the male rat
Keywords: گیرنده NK1; Nociception; Pain; Trigeminal; Orofacial; Substance P; NK1 receptor; Parabrachial; Descending inhibitory control;
Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries
Keywords: گیرنده NK1; Substance P; NK1 receptor; Endothelium-dependent contraction; Endothelium-dependent relaxation; Rabbit pulmonary artery; Regional difference
Modulation of anxiety in rats evaluated in the elevated T-maze: Evidence of the relationship between substance P and diazepam
Keywords: گیرنده NK1; Substance P; NK1 receptor; Diazepam; Elevated T-maze; Anxiety; Memory
The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor
Keywords: گیرنده NK1; Substance P; Tachykinin; NK1 receptor; G protein coupled receptor; Nuclear magnetic resonance; Receptor binding; Calcium responses; Desensitization
Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones
Keywords: گیرنده NK1; Electrophysiology; Dorsal horn; Alpha2-adrenoceptors; Descending inhibition; NK1 receptor
The Effect of Neurokinin1 Receptor Blockade on Territorial Aggression and in a Model of Violent Aggression
Keywords: گیرنده NK1; Aggression; amygdala; glucocorticoid; NK1 receptor; Substance P; violence
Decreased Substance P and NK1 Receptor Immunoreactivity and Function in the Spinal Cord Dorsal Horn of Morphine-Treated Neonatal Rats
Keywords: گیرنده NK1; Opiate tolerance; substance P; NK1 receptor; spinal cord; whole-cell voltage clamp
Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla
Keywords: گیرنده NK1; Nociception; NK1 receptor; Pain; Analgesia
Design, synthesis, and structure–affinity relationship studies in NK1 receptor ligands based on azole-fused quinolinecarboxamide moieties
Keywords: گیرنده NK1; Neurokinin; NK1 receptor; Substance P; Synthesis; Amide derivatives
Lasting changes in social behavior and amygdala function following traumatic experience induced by a single series of foot-shocks
Keywords: گیرنده NK1; PTSD; Trauma; Social behavior; Amygdala; CRF; NK1 receptor;
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists
Keywords: گیرنده NK1; SP; Substance P; ASMSP; acetyl-[Arg, Sar9, Met (O2)11]-SP (6-11); GR73632; [delta Ava [l-pro9, N-MeLeu10] SP (7-11)]; GR159897; [5-Flouro-3-[2-[4-methoxy-4-[[(R)-phenylsulphinyl] methyl]-1-piperidinyl] ethyl]-1H-indole]; GR64349; [[Lys3, Gly
Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents
Keywords: گیرنده NK1; NK1 receptor; Substance P; Antidepressant; Anxiolytic; Vestipitant; Extracellular-Regulated-Kinase