کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8686484 | 1580690 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
⺠Substance P (SP) is able to reduce significantly in G93A cortical neurons the kainate-induced currents and the mEPSCs. ⺠The effect is blocked by GR 82334, a NK1 competitive antagonist of SP receptor. ⺠Western blot and immunocytochemistry analysis indicate a higher NK1 expression level in G93A compared to Control cultures. ⺠Toxicity experiments reveal that SP is able to rescue G93A cortical neurons to a greater extent than Control neurons. ⺠The indication of a protective role of SP in the G93A mouse suggests an use of SP as a clinical therapeutic treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 44, Issue 1, October 2011, Pages 92-101
Journal: Neurobiology of Disease - Volume 44, Issue 1, October 2011, Pages 92-101
نویسندگان
Silvia Caioli, Livia Curcio, Massimo Pieri, Alessia Antonini, Roberta Marolda, Cinzia Severini, Cristina Zona,