کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6259471 | 1612996 | 2013 | 8 صفحه PDF | دانلود رایگان |
Alzheimer's disease (AD) is the most prevalent form of dementia. Intracerebroventricular (ICV) infusion of streptozotocin (STZ) provides a relevant animal model of chronic brain dysfunction that is characterized by long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit. Numerous studies on green tea epigallocatechin gallate (EGCG) demonstrate its beneficial effects on cognition and memory. As such, this study evaluated, for the first time, the effects of sub-chronic EGCG treatment in rats that were submitted to ICV infusion of STZ (3 mg/kg). Male Wistar rats were divided into sham, STZ, sham + EGCG and STZ + EGCG groups. EGCG was administered at a dose of 10 mg/kg/day for 4 weeks per gavage. Learning and memory was evaluated using Morris' Water Maze. Oxidative stress markers and involvement of the nitric oxide (NO) system, acetylcholinesterase activity (AChE) and glucose uptake were evaluated as well as glial parameters including S100B content and secretion and GFAP content. Our results show that EGCG was not able to modify glucose uptake and glutathione content, although cognitive deficit, S100B content and secretion, AChE activity, glutathione peroxidase activity, NO metabolites, and reactive oxygen species content were completely reversed by EGCG administration, confirming the neuroprotective potential of this compound. These findings contribute to the understanding of diseases accompanied by cognitive deficits and the STZ-model of dementia.
⺠Oxidative stress is implicated in the basis of clinical and experimental dementia ⺠Epigallocatechin gallate (EGCG) has been proposed as a neuroprotective compound ⺠EGCG reversed cognitive deficit in streptozotocin-model of dementia ⺠EGCG reversed changes in reactive oxygen species in STZ-model of dementia ⺠EGCG also reversed the increment of acetylcholinesterase in this model.
Journal: Behavioural Brain Research - Volume 236, 1 January 2013, Pages 186-193