Research reportNeuroprotective action of proline-rich polypeptide-1 in β-amyloid induced neurodegeneration in rats

It is recognized that the main trigger of Alzheimer disease related neurodegeneration is β-amyloid peptide, which subsequently generates different metabolic disorders in neuron and finally leads to neuronal death. Several biologically active products were tested as neuroprotectors, but only few of them demonstrated any efficiency.Proline-rich polypeptide-1 was tested as a neuroprotective agent on Aβ25-35 animal model of Alzheimer disease. Biochemical analysis (determination of spectrum of neuroactive amino acids, such as glutamate, gamma-aminobutyric acid, glycine, aspartate and taurine), as well as behavioral, electrophysiological and morphological studies were performed to reveal the neuroprotective potential of proline-rich polypeptide in rats.Based on the results of our study it can be concluded that proline-rich polypeptide-1 has a potential to be one of the effective preventive or therapeutic agents against neurodegenerative disorders, such as Alzheimer disease.

► PRP-1 leads to increase in the level of all amino acids, except taurine in control. ► Aβ exposure was expressed by default in taurine level, which is prevented by PRP-1. ► PRP-1 treatment recover PTP induced by TD. ► PRP-1 improves spatial alteration level compared with amyloid treated group. ► PRP-1 markedly enhances the structural integrity of neurons compared with Aβ.