کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6262298 | 1613795 | 2016 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ReviewRoles for RNA-binding proteins in development and disease ReviewRoles for RNA-binding proteins in development and disease](/preview/png/6262298.png)
- RBPs can be developmentally regulated for normal RNA metabolism.
- RBPs are mis-regulated in certain diseases (e.g. DM and ALS).
- This minireview stresses the importance of proper RBP level and localization.
RNA-binding protein activities are highly regulated through protein levels, intracellular localization, and post-translation modifications. During development, mRNA processing of specific gene sets is regulated through manipulation of functional RNA-binding protein activities. The impact of altered RNA-binding protein activities also affects human diseases in which there are either a gain-of-function or loss-of-function causes pathogenesis. We will discuss RNA-binding proteins and their normal developmental RNA metabolism and contrast how their function is disrupted in disease.This article is part of a Special Issue entitled SI:RNA Metabolism in Disease.
Journal: Brain Research - Volume 1647, 15 September 2016, Pages 1-8