کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262663 1292373 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportEpigenetics and therapeutic targets mediating neuroprotection
ترجمه فارسی عنوان
گزارش تحقیقاتی و پیشگیری از اپی ژنتیک و اهداف درمانی محافظت از عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Epigenetic phenomena orchestrate nervous system structure and activity across the lifespan.
- Epigenetic mechanisms also mediate neural cell injury and countervailing neuroprotective responses.
- Epigenetics has the potential to identify transformative therapeutic targets for adult onset neurodegenerative disorders.

The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses.This article is part of a Special Issue entitled SI: Neuroprotection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1628, Part B, 2 December 2015, Pages 265-272
نویسندگان
, ,