کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263926 1613933 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportAltered auditory processing in a mouse model of fragile X syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportAltered auditory processing in a mouse model of fragile X syndrome
چکیده انگلیسی

This study provides the first description of auditory cortical processing in a mouse model of Fragile X Syndrome (FXS). FXS is a genetic cause of intellectual impairment and is an autism spectrum disorder. Human studies with auditory evoked potentials indicate that FXS is associated with abnormal auditory processing. The Fmr1 knock-out (KO) mouse is a useful model for studying FXS. The KO mice show acoustic hypersensitivity and propensity for audiogenic seizures, suggesting altered auditory responses. However, the nature of changes at the neuronal level is not known. Here we conducted in vivo single unit extracellular electrophysiology in the auditory cortex of urethane/xylazine-anesthetized Fmr1 KO mice in response to tones and frequency modulated (FM) sweeps. Using tones as stimuli, we report expanded frequency tuning, enhanced response magnitude, and more variable first spike latencies in Fmr1 KO mice compared to wild-type controls. FM sweep stimuli revealed altered sensitivity to the rate of frequency change indicating abnormal spectrotemporal processing. There was no difference in FM sweep direction selectivity. Consistent with studies of the somatosensory cortex, these data point to hyper-responsiveness of auditory neurons as a key processing abnormality in FXS. Auditory neural responses can serve as outcome measures in preclinical trials of therapeutics for FXS as well as serve as physiological probes to study their mechanisms of action.

► This study examined auditory cortical processing in a mouse model of Fragile X Syndrome. ► Neurons of the auditory cortex of Fmr1 KO mice were hyper-responsive to tones. ► Variability in response latency, broader frequency tuning and altered spectrotemporal processing were also seen. ► These data may serve to explain auditory deficits in humans with Fragile X Syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1506, 19 April 2013, Pages 12-24
نویسندگان
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